Personal Statement (limit 1 page): Please include your primary research interests and explain how this training will advance your short, medium, and long-term career goals
Three reference letters of support, with one from current Department Head confirming secured position upon return to home institution and protected research time.
University of Port Harcourt, Choba Port Harcourt.
I am a research Scientist in the field of Pharmacology who is intensely interested in cancer research for the development of newer drugs that are less toxic directed to attack cancer cells with reduced toxicity to normal cells. My primary research interest is Cancer Chemotherapy. This training in very important to me because, it will help me to develop more skills in cancer research for the purpose of testing several natural remedies for their anti- cancer potentials for the purpose of discovery of effective and less toxic remedies for cancer treatment. This training will give me both a short and long term opportunity of research techniques in cancer studies and will help me, my institution, my students and the general population as we begin with innovative discoveries in cancer care and therapy.
University of Medical Sciences, Ondo City, Ondo State, Nigeria
Breast cancer (BC) is currently the most diagnosed cancer and the fifth cause of cancer-related deaths globally. Although it can be successfully treated if diagnosed early, reducing mortality, BC causes the most cancer-related deaths in women, especially in low and middle-income countries (LMICs) like Nigeria. Despite efforts to address racial health disparities in BC burden, geographical variations from low-resourced settings reveal an increasing record-high BC burden in LMICs as most studies and advances are carried out in North America and Europe.
Africa is the most genetically diverse population with complex multifactorial diseases, yet its genome is largely unexplored due to insufficient resources, technical know-how and human capacity to tackle the growing challenge. In Nigeria, the paucity of data to make informed decisions towards prevention, diagnosis and treatment calls for the need for collaborative research to understand BC dynamics and generate evidence-based regional data, including predisposing factors to BC. Therefore, I wish to collaborate with Scientists in my field to do research that will help us understand and appropriately tackle BC in Nigeria, reducing the disease burden.
The contribution of genetics to the pathogenesis of breast cancer in Africa remains largely unexplained. Therefore, I am interested in the Molecular epidemiology of breast cancer and its translation to address current public health needs in Nigeria. My primary research goal is to apply molecular techniques and methods to investigate somatic events predisposing Nigerian women to BC and to help contribute comprehensive genetic data in explaining the role of somatic events in breast pathogenesis. Also, to develop resources that could lead to the molecular detection of individual BC risk, early detection, therapeutic options, and improved survival and quality of life in Nigerian women.
The gut microbiome (GM) has recently been determined as an additional environmental risk factor for somatic BC due to its role in estrogen metabolism leading to high levels of circulating estradiol and estrogen alteration. However, the exact mechanism of the GM dysbiosis (imbalance of the gut microbiota) implication in BC is still unclear. Therefore, my short-term goal is to describe the GM profile of BC patients in Nigeria and novel population-specific and medically relevant microbiome signatures in the West African population. My medium-term goal is to use metagenomics tools to describe both the taxonomical and functional characteristics of GM and to investigate the role and impact of GM dysbiosis in breast oncogenesis, tumour characteristics, known risk factors and treatment outcomes in Nigerian BC patients and women of West African descent. I also seek to determine the different pathways by which the GM imbalance mediates BC progression, metastasis, treatment response, and survival outcomes. My long-term goal is to develop Nigerian-specific BC cell lines to drive research. Also, to be able to impact BC prognosis and diagnosis by using the GM composition as a biomarker to detect the presence of BC in individuals that could be harbouring cancer cells. Manipulating the GM composition could lead to entirely new ways of treating BC by decreasing tumour-promoting bacteria or boosting tumour-protective bacteria.
This postdoctoral training will propel me towards achieving these goals by equipping me with the necessary research tools and resources. By interacting with experts in the field, I hope to glean from their wealth of knowledge and experiences. I am seeking the opportunity to expand my horizon and knowledge on the current advances in genomic research, and to significantly push the frontiers of BC research in Nigeria by collaborating with other Scientists. I hope to acquire tools for research analysis, implementation of outcomes and linkage of my research output to relevant stakeholders for proper execution. I will have the much-needed mentoring in my chosen career path and gain significant knowledge on the implication of ethical/social issues in genetics research to improve the quality of life for BC patients. With my collaborators, I hope to develop methods and approaches to implement, strategize and establish sustainable and inclusive programmes tailored toward achieving my desired goals of reducing the BC burden in Nigeria and globally
University of Medical Sciences, Ondo City, Ondo State, Nigeria
Breast cancer (BC) is currently the most diagnosed cancer and the fifth cause of cancer-related deaths globally. Although BC can be successfully treated if diagnosed early, thus reducing mortality, it causes the most cancer-related deaths in women, especially in low and middle-income countries (LMICs) like Nigeria. Despite efforts to address racial health disparities in BC burden, geographical variations from low-resourced settings reveal an increasing record-high BC burden in LMICs as most studies and advances are in North America and Europe. Africa is the most genetically diverse population with complex multifactorial diseases yet its genome is barely unexplored due to insufficient resources, technical know-how and human capacity to tackle the growing challenge. In Nigeria, the lack of data to make informed decisions towards prevention, diagnosis, and treatment calls for collaborative research to understand BC dynamics and generate evidence-based regional data, including predisposing factors to BC. Therefore, I wish to collaborate with other researchers in my field to do research that will help us understand and appropriately tackle BC in Nigeria and reduce the disease burden. The contribution of genetics to the pathogenesis of breast cancer in Africa remains largely unexplained. Therefore, I am interested in the Molecular epidemiology of breast cancer and its translation to address current public health needs in Nigeria. My primary research goal is to apply molecular techniques and methods to investigate somatic events predisposing Nigerian women to BC, including epigenetic mechanisms, to contribute comprehensive genetic data to help explain the role of somatic events in breast pathogenesis. Also, to develop resources that could lead to the molecular detection of individual BC risk, early detection, therapeutic options, and improved survival and quality of life for Nigerian women. The gut microbiome (GM) has recently been identified as an additional environmental risk factor for somatic BC, particularly, due to its role in estrogen metabolism leading to high levels of circulating estradiol and estrogen alteration but the precise mechanism of the GM dysbiosis (imbalance of the gut microbiota) implication in BC is still unclear. Therefore, my short-term goal is to describe the GM profile of BC patients in Nigeria and novel population-specific and medically relevant microbiome signatures in the West African population. My medium-term goals are to use metagenomics tools to describe both the taxonomical and functional characteristics of the GM and to investigate the role and impact of GM dysbiosis in breast oncogenesis, tumour characteristics, known risk factors and treatment outcomes in Nigerian BC patients and women of West African descent. I also seek to determine the different pathways by which the GM imbalance mediates BC progression, metastasis, treatment response, and survival outcomes. My long-term goal is to develop Nigerian-specific BC cell lines to drive research. Also, to be able to impact BC prognosis and diagnosis by using the GM composition as a biomarker to detect the presence of BC in individuals that could be harbouring cancer cells. Manipulating the GM composition could lead to new ways of treating BC by decreasing tumour-promoting bacteria or boosting tumour-protective bacteria. This postdoctoral training will propel me towards achieving these goals by equipping me with the necessary research tools and resources. By interacting with experts in the field, I hope to glean from their wealth of knowledge and experiences. I seek the opportunity to expand my horizon and knowledge on the current advances in genomic research and to significantly push the frontiers of BC research in Nigeria by collaborating with other Scientists. I hope to acquire tools for research analysis, implementation of outcomes and linkage of my research output to relevant stakeholders for proper execution. I will have the much-needed mentoring in my chosen career path and gain significant knowledge on the implication of ethical/social issues in genetics research to improve the quality of life for BC patients. With my collaborators, I hope to develop methods and approaches to implement, strategize and establish sustainable and inclusive programmes tailored toward achieving my desired goals of reducing the BC burden in Nigeria and globally.
Psychological burdens of distressed cancer patients Coping with emotional traumatic cancerous metastasis, tumor healing and mental health of chronic cases of cancer and other diseases
The extent to which researchers are able to make additional improvements in the health of the public depends, mostly upon the quality and preparedness of the public health workforce, which is consequently dependent upon the relevance and quality of its education and training. Cancer and it’s effects on Mental health has, for people who care about the greater good of humanity,drawn great concerns globally . Despite a handful of mental health initiatives that has been put in place to ensure and improve the conditions and behaviours that affect people’s emotional health ,not all people can attain it.. It is my hope that with the center that unites scholars, researchers and entrepreneurs towards the common goal of solving some of the world’s toughest challenges,. I believe that this an idea-led and research-led academic hub with spectacular track record, which will transform industries. I am excited about the prospect of joining an academic institution with great curriculum that will provide me with the best platform to learn, launch my career and attain my plans for promoting the health of the entire population.
Apart from contributing towards enriching the work , I believe I will make an invaluable addition and will be able to bring the perspective I have gained from my personal experiences, growing up in a diverse and multicultural environment. I am confident that my passion and determination fits well with the disciplined work ethics and forward-thinking approach . I hope that on consideration of my application, you will be convinced of my potential to make a real contribution in the program as well provide me the platform to attain my dream of promoting health and wellness of many chronic situations like cancer. The reduction of diseases and sensitization of the general public on best health -practices for cancer and Mental health Mental health programs help maintain the emotional support that retains the life of people and this is important since the mental health initiatives affect people, every day in every part of the world. The top causes of death are suicide commencing from suicidal ideation and major depressive states which mostly occur from the chronicity of diseases etc. People will continue to die unnecessarily from preventable conditions, if proper programs are not put into place. This fueled my zeal to maintain my research on mental health and cancer, at a post graduate level so as to play my part to help proffer and implement solutions to tackle the poor quality of health services and provide more mental health education in my country.
Some of my career goals are to gain New Skills, strive for excellence, boost my networking abilities and become an Expert in my field and enhance proper design of programs to address the cases with mental health problems .this will go a long way in improving the health status of the common man. I have always had a passion to support sick people with emotional problems . My desire to change the Nigerian healthcare system got aroused as a child when one of my siblings had to make uncountable visits to the hospital over the course of months to secure just one appointment with an oncology doctor for a disturbing growth in the neck which later triggered mental distress after the protracted illness. The situation aggravated and there was no help anywhere. As I grew older my passion evolved and I went on to study bachelor for NURSING sciences at the undergraduate level which exposed me to a rich variety of disciplines related to human health. Mental health in cancer cases , is a vast area of research that yields profound discoveries of new scientific approaches and techniques that advance our understanding of the structures and processes that underpin human health and diseases which have the potential to transform global healthcare. I am a registered nurse midwife , a nurse educator and public health NURSE ,with a masters degree in mental health , i am also a faculty staff for clinical sciences at University of Ilorin , Kwara State Nigeria and have done some researches For the past 10years, i have been into several hands-on skills, demonstrating clinical nursing procedures,I have several years of experience as a clinical nurse in the teaching hospital and subsequently as nurse educator, i still lecture a variety of students and foreign students from university of Ilorin,who work with me, to be registered with the Nursing AND Midwifery Council of Nigeria..i have worked with some academicians to also publish research papers in nursing, psychiatry and beyond
Outcome research in the following areas: 1. Clinical Pharmacy 2. Oncology: breast cancer, cervical cancer, prostrate cancer 3. Community pharmacy 4. Public health
Personal statement I have always had this desire to positively improve the quality of life of cancer patients and be part of a team that can develop agents that eradicate cancer. This desire heightened when I lost dear relatives to cancer. As a result, I enrolled in post-graduate fellowship training with the West African Postgraduate College of Pharmacists (WAPCP) to specialize in oncology pharmacy. As part of my fellowship training requirements, I conducted a research where we developed and validated a self-management scale for breast cancer patients in two tertiary hospitals in Southeastern Nigeria. With this scale, we determined the level of self-management among breast cancer patients in Anambra State, Nigeria. This research study exposed us to the needs and concerns of breast cancer patients in Anambra State, Nigeria. A paper on this study in which I am the first author is under communication. For my Ph.D., we developed and validated quality indicators for assessing pharmaceutical care performed in community pharmacies in Anambra State, Nigeria, and determined the level of pharmaceutical care performance in the community pharmacies using the developed indicators. An article on that study in which I was the first author has been published and included in my publication list. My research interests include outcome research in clinical pharmacy, community pharmacy, pharmaceutical care, and oncology research: breast cancer, cervical cancer, and prostate cancer. My decision to apply for the Memorial Sloan Kettering Cancer Center-ARGO Cancer Post- My Doctoral Research Training Position is to further develop my research skills in oncology through mentored training by experts in oncology research and collaboration with other post-doctoral researchers around the world. Memorial Sloan Kettering Cancer Centre is the largest and oldest private cancer center in the world, and one of the 52 National cancer institutes designated cancer centers for training many medical residents, fellows, and post-doctoral researchers. My ultimate career goal is to head a research team whose aim will be to conduct research that will improve and increase survivorship in cancer patients. I seek to become a professor in a research-based institute with adequate resources that will enable me to conduct outcome-based research studies in oncology, clinical pharmacy, community pharmacy, and public health. I also wish to serve as a mentor to upcoming researchers, especially in Nigeria, with a limited number of researchers in oncology. Participating in this post-doctoral training will be ideal preparation for achieving my career goals.
Genomics of Infectious Diseases and Cancer. Cancer Biology and Cancer Biomarkers
School of Post Basic Midwifery, Obafemi Awolowo University Teaching Hospitals Complex, Wesley Guild Hospital, Ilesa, Osun-State, Nigeria.
Oncology (Cervical Cancer)
My area of research interest is cervical cancer focusing on the preventive measures through primary and secondary prevention via vaccination, screening and treatment of pre-cancer lesions. Cervical cancer has been identified as the fourth most common cancer among women globally, and an estimated 604 000 new cases and 342 000 deaths recorded in 2020. It was also revealed that about 90% of the new cases and deaths worldwide in 2020 occurred in low- and middle-income countries. (WHO, 2022). Inadequate information, awareness and access to effective screening for cervical cancer contribute to the high morbidity and mortality caused by the disease I am interested in carrying out a research study on the effect of educational package on uptake of cervical cancer prevention (primary and secondary) among girls and women of reproductive age in the South Western part of Nigeria using mixed method. This is because, vaccination against Human Papilloma Virus (HPV), screening and treatment of pre-cancer lesions are cost-effective way in the prevention of cervical cancer. This training organized by Memorial Sloan Kettering Cancer Centers’ Global Cancer Disparities Initiatives (GCDI) and the African Research Group for Oncology (ARGO) will widen my horizon and improves my competence in research writing. It will assist me to be able to carry out outstanding research in oncology that can improve the outcomes of Nigeria cancer patients. In addition, the program will assist in my carrier progression as a Nurse Researcher and academia.
UNIVERSITY OF BENIN, BENIN CITY, EDO STATE NIGERIA
My desire to focus my research interest in neuro oncology nursing was established years ago after my first work placement at a hospital where I later acquired a paid job as a nurse assistant. These desire was further enhanced by my time the university, during my first degree in nursing and subsequently I developed a strong likeness for medical surgical nursing where I specialized in during my master and Ph.D degree with subspecialty in neurological/critical care nursing In order to explore oncology care in greater depth, I registered and completed an online course on cancer/palliative care from Africa Palliative Care Association in collaboration with ecancer, Cardiff University and International Atomic Energy Agency. This has further exposes me to the need and challenges of neuro oncology nursing care services in Africa as well as its management. This no doubt has strengthen my ability and capacity to engage in this research area. With my drive and passion to progress in my career in nursing as a researcher, I have an academic position currently lecturer1 in a reputable university in Nigeria and with over forty (40) published articles in recognised local and international journals. This has indeed broadened my horizon in research, critical thinking and analytical mind which are one of the main qualities of a good researcher. My short and medium term goal is to be fully equipped with the capacity both in knowledge and skills in conducting cutting- edge researches. My ultimate career goal is to become an independent researcher at an academic institution and to establish a laboratory that studies nursing management of patients with neuro oncology cases. Conducting cutting-edge research and helping to improve the quality of lives of patients with neuro oncology cases in Nigeria African and the World at large. Many challenges are abound in neuro oncology care especially in the developing countries like Nigeria that are begging for answers and solutions. Pushing my limit as far as they could go and extending current thinking into new paradigms, I will revolutionized the field of nursing and more likely defining an entire new field of neuro oncology in nursing. Having this postdoctoral fellowship done at Memorial Sloan Kettering Cancer Centers’ Global Cancer Disparities Initiatives (GCDI) Program and the African Research Group for Oncology (ARGO) which focused on improving outcomes for Nigerian cancer patients will be a great opportunity. The environment being purely a research institute will provide access to various resources that will greatly enhance and enrich my training program, including access to cutting-edge technologies, proximity to other institutes to foster collaborations and networking, and journal clubs and/or seminar series that will expose me to invited speakers. This of course will help me achieve my future goal.
Oncology, End of Life Care/ Palliative Care, Men’s health, Pressure ulcers/Burns, HIV/AIDS, Quality of life
The researcher primary area of interest is on Prostate Cancer (PC) and specifically to research into Prostate cancer educational intervention as a strategy for enhancing knowledge and screening practices of men in selected Communities in Southern, Nigeria as well as effect of church-based intervention to promote informed decision making for prostate cancer screening among adult men attending Orthodox and Protestant churches in Southern Nigeria. According to American Cancer Society (2020) health care providers should offer a prostate specific antigen (PSA) test and a digital rectal examination (DRE) yearly, beginning at age 40 especially black men who have a first-degree relative who was diagnosed with prostate cancer before age 65. Researchers agreed that regular screening and examination with the PSA and DRE can result in detection of prostate cancer when treatment is more likely to be successful and may detect significant prostate cancer at earlier and more favorable stages. Most researchers revealed that most Nigerian men do not know where to go for prostate cancer screening and recommend that prostate cancer related public enlightenment should be organized, especially for males and their spouses in order to enable them to make informed decision about going for prostate cancer screening and improve the low level of awareness that males have on prostate cancer screening. The training could increase public awareness in the community regarding prostate cancer and importance of prostate health screening among male population. This is particularly important to the elderly who are at risk of developing prostate gland abnormalities and to those high-risk groups or individuals prone to develop prostate cancer. The training will increase knowledge about PC and its early detection measures. This will help men to appreciate the need for practice of early detection measures and ensure the ability to recognize the signs and symptoms of PC. The training will promote the activities of policy makers to formulate health policy for that age group towards prostate cancer knowledge and screening uptake and also inculcate prostate cancer awareness and screening uptake in the nursing curriculum and practice. The long term career goals of the training will be to generate evidence to inform policy makers on the need for ‘Well Men Clinics’ in institutions where men can go and get counseling on health matters and be enlightened about the benefits of prostate cancer screening.
Faculty of Nursing Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti, Ekiti State, Nigeria
Health literacy, Family health, Disease Prevention and Health promotion
I began my career in nursing in the late 70s with a desire to impact positively on humanity through caring for the sick. After working for more than 2 decades, I wish I could do better but needed additional knowledge. This prompted me into going into the university for 1st, 2nd and a 3rd degree in nursing. Over the years I have worked in the clinical, administrative and academics areas in nursing and this has given me experiences in all these areas. I currently work as a senior lecturer and a head of department of community/public health in the faculty of nursing in a private university. Apart from conducting personal researches, I have been engaged in supervision of researches of undergraduates and recently Master and doctoral students. My career goals are to conduct researches to discover new ideas and contribute to existing knowledge that will improve nursing practice and health outcomes. This post-doctoral research training will be a privilege to learn the necessary skills. My primary area of research interest is health literacy, disease prevention, health promotion and family health. I conducted a study in this field as my PhD thesis. (Development and validation of health literacy assessment tool for health promotion among adults in Ondo State, Nigeria. Health literacy it’s a new field with less work done in Nigeria. Health literacy impacts health outcomes which cover both medical and public health areas. Improvement of health literacy is an important strategy in disease prevention, health promotion and self-care. Improving health literacy is very crucial to improving health outcomes for Nigerian cancer patients. This makes my area of research interest relevant to this program. My short goal is to conduct study to determine the health literacy of population. My medium goal is to improve health literacy through interventions to improve knowledge, skills & capacity for self-care, health promotion behavior, utilization of health services. Long term goal is to increase routine screening of health services and monitor health promotion behaviors. With my past experience in research, I have the skills in conceptualizing a study, conduct literature search, develop appropriate methodology, present, interpret and discuss findings logically.
DEPARTMENT OF NURSING SCIENCE, FEDERAL UNIVERSITY BIRNIN KEBBI, KEBBI STATE NIGERIA.
My research interest is in cervical cancer and community health. My first Ph.D. study was on Cervical cancer. My second Ph.D. is also on Cervical Cancer. I have a passion to prevent the disease among women, reduce the incidence and prevent women from dying from cervical cancer. I have carried out several types of research on cervical cancer, some still ongoing, and presented papers at conferences on cancer. I have published some articles on cervical cancer in reputable journals and served as a reviewer for some local and International Journals articles related to cancer research. I have attended workshops for cervical cancer prevention and organized free screening for women with cervical cancer in my institution. I teach Oncology to both undergraduate and Postgraduate students at the University and care for patients with cancer. I also supervise students’ projects on oncology. My research interest is in Cervical Cancer. Cervical cancer is the second most common cancer among women in Nigeria. Cervical cancer is the most common cancer among women in 36 low-and middle-income countries, mainly in sub-Saharan Africa. It killed an estimated 341,843, women in 2020, 90% of whom were in less-developed regions of the world, where access to prevention, screening, and treatment services is severely limited (WHO, 2020). The disease reflects inequities among different populations depending on the availability of a national vaccination program and population-based cervical cancer screening, and access to quality treatment (Ginsburg, Bray, Coleman, et al., 2017). A lot of women in my region presented to the hospital late with the disease condition and later died. Knowledge about preventive services among women is minimal. I hope to change the narrative by gaining more knowledge and skills on how to prevent women from this dreaded disease.
I wish to apply for a Post-Doctoral position at your institution. I am Dr. Anita Y. Mfuh. I am a lecturer in the Department of Nursing Sciences, Federal University Birnin Kebbi. I started work at Ahmadu Bello University Zaria, Nigeria in June 2005. I had a Ph.D. in 2016, a Master’s degree in 2010, and a Bachelor’s degree in Nursing Sciences in 2004. Due to my outstanding performance as an undergraduate student, I was employed in the Department of Nursing Science in 2005 where through the years I was able to study for higher degrees and rose to the rank of Senior Lecturer in 2017 awaiting my Professorial promotion. I am a Fellow of the West African College of Nursing and was the Chairperson for the Faculty of Community Health Nursing till 2021. I was the National Secretary of the Nigerian Association of University Nursing Programmes for the past seven years. I have been teaching different courses to both Undergraduate and Postgraduate students as well as supervising both undergraduate and Postgraduate (MSc, Ph.D.) research in both Nursing Sciences and the department and Sociology Department. My research interest is in cervical cancer and community health. My first Ph.D. study was on Cervical cancer. My second Ph.D. is also on Cervical Cancer. Presently carrying out research on cervical cancer. I have a passion to prevent cervical cancer among women, reduce the incidence and prevent women from dying from cervical cancer, especially in hard-to-reach areas. I have carried out some research on cervical cancer, some still ongoing, and presented papers at conferences on cancer. I have published some articles on cervical cancer in reputable journals and served as a reviewer for some local and International Journals articles related to cancer research. I have attended workshops for cervical cancer prevention and organized free screening for women for cervical cancer in my institution. I teach Oncology to both undergraduate and Postgraduate students at my University and others and care for patients with cancer. I also supervise students’ projects on oncology. Cervical cancer is the second most common cancer among women in Nigeria. The incidence is higher in my region (Northern Nigeria) where literacy level is very low, especially among females and early marriage is common. Cervical cancer is preventable and treatable, yet the burden is still high among women in my region. Most women are ignorant about preventive measures. Short-term goal: Acquire knowledge and skills that will help in the early diagnosis of cervical cancer. Medium goal: To be able to treat cancer and its complications Long-term career goals: To prevent cervical cancer and reduce its prevalence.
Federal University of Health Sciences, Otukpo (FUHSO), Benue State, Nigeria
Blood transfusion and Haemato-Oncology
A One-year Postdoctoral Research Position at Memorial Sloan Kettering Cancer Center, New York.
I am writing to you to express my interest in the Postdoctoral Researcher Position in Blood Cancer Research. When reviewing the position requirements, I was excited to find that my qualifications, experiences and personal strengths align with your needs and mission.
I am an active researcher and have conducted and published works in Haematological Malignancies with about twenty-eight scientific publications in reputable journals.
My primary research interest is Blood Transfusion Medicine and Haematological Malignancies (Blood Cancers).
I believe that this training will advance my short, medium and long-term career goals as follows:
i. Short-term goal will be to conduct basic and preventive care research to identify those at-risk of blood cancers. This will involve research into the risk factors, symptoms, family history and sociodemographic characteristics of healthy individuals in the community who may be at risk of developing blood cancers. Research questions that will identify these risk factors will help in early detection or prevention which may help to control blood cancers. This will be most useful in my locality which is an under-studied and low-resourced developing country. The second phase will be to identify reliable blood screening tests for those at risk of blood cancers identified in the first phase described earlier.
ii. My medium-term goal will be on clinical and translational research into near-precision diagnostic techniques for haematological malignancies. I will be interested in exploring more innovative ways of deploying immunophenotyping and Molecular techniques to low-resourced settings for the diagnosis of haematological malignancies.
iii. My long-term goal will be on alternative targeted therapeutic options for haematological malignancies through dissemination and implementation research for system-wide change and improved access in poor-resources settings.
Please, review my enclosed resume for a more in-depth illustration of my work, history and accomplishments.
Michael A. Onoja
Behavioral Science (Psycho-oncology)
Department of Psychology, University of Nigeria, Nsukka
Psycho-oncology, psychological wellbeing, Health systems and health policy, development studies, and forensic psychology
I write to humbly express my interest in the Memorial Sloan Kettering Cancer Center-ARGO Cancer Post-Doctoral Research Training Positions. Following the completion of my postgraduate studies, I am looking towards opportunities to broaden my research knowledge and apply my skills to translational research in psycho-oncology and beyond. Although I completed post graduate training in forensic (MSc) and clinical psychology (PhD) in July 2021, I have continued to apply my research skills in practical problems facing my immediate society. This has led me to be involved in multidisciplinary projects that aim to tackle problems in oncology, health systems, drug abuse/mental health, education, and in the development sector. I got into oncology research in 2015 when I volunteered to work as a research associate with Project PinkBlue, a leading cancer advocacy, non-governmental organization(NGO) in Nigeria. I went beyond research to community engagement when I realized the burden of cancer in Nigeria, majorly driven by poor awareness and misconceptions that result in late diagnosis. This led the NGO to award me the Most Dynamic Volunteer Award in 2019. In the same year, I also received scholarship from the International Psycho-Oncology Society (IPOS) to attend a workshop on palliative and end of life care for cancer patients in Maputo, Mozambique. I have since worked closely with the NGO, carrying out research and presenting in local and international conferences. I have grown to learn of other health system inefficiencies that impede access to cancer care in Nigeria. I have seen firsthand the difficulty in accessing cancer care and I am moved to assist in my capacity as an academic researcher. I actively seek opportunities to train and learn in places with better oncology care experiences so that I can learn and contribute to the situation back home in Nigeria. I have worked in research/advocacy projects for breast and prostate cancer patients in Africa, and especially in Nigeria, where the aim includes boosting early detection as well as establishing on-line and offline support platforms that will ease the difficulty in accessing care. In the next 2 years, I hope to influence my Faculty/Department to begin to consider psycho-oncology in her clinical and counseling programs by including course modules and posting students to oncology units for internships. In 5 years, I plan to attract postgraduate supervisees who will be interested in researching and publishing on cancer care and psycho-oncology issue in Nigeria. In 10 years, I hope to contribute to the development of a psycho-oncology progam (perhaps within the health psychology discipline), and graduating students in this specialty. My diverse postgraduate training experience was for me a unique capacity building exercise, as I strived to pick skills that will help me to think and relate to problems beyond my immediate academic background (psychology). Although I qualify and practice as a clinical and forensic psychologist, and as well teach in the University of Nigeria, I am largely invested in research,- problem solving research. This passion for translational research arose from my living in Nigeria, a society where we face numerous problems, across many sectors. This diverse experience mean that I am skilled in diverse quantitative (statistical analysis) and qualitative (such as interviews, focus group discussion and ethnography research skills). I have published over 30 articles in highly visible international journals. I strongly believe that an opportunity to partake in the postdoctoral training in Sloan Kettering Cancer Centre will enable me broaden my research skills and build research capacity and competency in oncology research. I also believe that it will be an opportunity for me to contribute to ongoing work in the Centre. I am willing to provide any other supportive document that you may require.
1. Preventive Oncology 2. Critical care Nursing with focus on Oncology care
Mobolaji-Olajide Oluwafunmilola ( RN, RM, RPHN, BNSC, M.Sc.N (Ife), Ph.D (Nursing) (Ife), ISN Fellow (Wits), FWACN) is a Lecturer at the Department of Nursing Science, Faculty of Clinical Sciences of the Universiy of Lagos. She has over twenty years of clinical, teaching, and research experience in Nursing. Her area of research interest includes prevention and management of patient with cancer, clinical / translational research in patients’ health cancer and research education. She focuses on preventive oncology in relation to diet and good health behaviours in long term management of patient in critical oncology conditions. Her credentials in this regard have been enhanced by her Doctor of Philosophy in Nursing (Ph.D) programme and a fellowship programme with the West African College Of Nursing in Medical surgical nursing specialty. She had not less than 23 publications to her credit in reputable journals.
Dr. Mobolaji-Olajide is actively involved in training and mentoring of both undergraduate and postgraduate students in Nursing and other allied health care Professionals and serves as an examiner to several universities and Nursing and midwifery Council of Nigeria. She is currently the Chief facilitator/coordinator of the Mandatory Professional Continuing Development Programme (MCPDP) for nurses in Lagos State Nigeria. Building upon these early career development opportunities and a rich environment at Memorial Sloan Kettering Cancer Center will enable her to quickly transit into independence, serving as the PI/co-PI on multiple grants and awards in Nigeria and all over the world. She had worked with some NGO’S and research institute such as Family Health Initiatives, Ile-Ife, Osun State and Pro-Health International to provide nursing care to the less privilege in the community and to conduct research. If giving this opportunity it will avail her a better opportunity to go into more collaboration with other researchers within and outside Nigeria in health care management, help in international collaboration in other to improve her nursing skills and grant writing skills, also help her to improve on her grant writing skill which will definitely have positive impact on the grant opportunities for younger faculty members of her university who will like to pursue their research focus in Oncology and help to speed up the formation of her planed research cluster here in Nigeria towards improvement in the nursing care giving to cancer patients in the hospitals; most especially centres with cancer focused facilities like Lagos University Teaching Hospital (LUTH), idi-Araba Lagos and University College Hospital (UCH), Ibadan both in Nigeria. It will also enable her to train nurses in preparation for quality care provision in the hospital settings.
Department of Nursing Science, Ekiti State University, Ado-Ekiti
I am a community health nurse and health services researcher, I employ quantitative and qualitative data to learn more about the social, cultural, economic, and political factors influencing people’s health, healthcare institutions, and treatment access. My research interests are focused on the sexual and reproductive health of every family member.
I am a dynamic nurse and lecturer with skills in both qualitative and quantitative research. My primary research interest is Sexual and Reproductive health of each member of the family. This Post-doctoral training will afford me the opportunity to achieve my immediate career goal of conducting high-quality research by building on foundational skills and knowledge I gained during my doctoral studies. My ability and skills in conducting independent research that advances nursing knowledge and interdisciplinary understanding of complex health issues will be enhanced by the training. The training will also assist me to have mentors who can assist me with scholarly activities and research training, as well as in developing individualized career plans, including proposals for post-fellowship career development. The training will also provide me with the concentrated time, resources, and support I need to advance my research skills and sustain an independent research career. It will help me achieve my intermediate career goal of improving my ability to obtain future research grant funding while also increasing my research productivity. My long-term goal of eliminating disparities in health care access, cancer, and other sexual and reproductive problems can be achieved through policy improvements suggested by quality research studies produced through this training.
Cancer genetics, Immunotherapy and computational oncology
PERSONAL STATEMENT FOR THE POSTDOCTORAL RESEARCH POSITION I am Imaobong Christopher Etti, Ph.D, a young and meticulous researcher with an unparalleled passion for cancer research. As a lecturer at the University of Uyo, Nigeria, my zeal and daily desire is to prevent and overcome the menace of cancer which has endeared my interest for the one-year postdoctoral research position at Memorial Sloan Kettering Cancer Center in New York. During my PhD research at the Universiti Putra Malaysia (UPM), I investigated the molecular mechanism of a pure compound, Artonin E from natural source on breast cancer using both in silico, in vitro and in vivo approaches. My thesis stood out in the faculty of Vertinary Medicine, during the 2017 session, this earned me the best Ph.D thesis award with a gold medal. For the past ten years of teaching Pharmacology and Toxicology in the University, my passion for research has motivated my mentoring of undergraduate and graduate students who have shown interest in cancer research in the biomedical sciences. During these years, I have made tremendous contribution in my Departments that resulted in my coordinating the postgraduate programme, a position I hold at the moment. My ability to work in a team has helped me organized graduate seminar presentations at the departmental as well as faculty level with good numbers of staff, students and the public in attendance. Given my experimental experience in cancer research, I would like to further explore more molecular biology-based techniques and experimental procedures using state-of-the-art equipment to elucidate the molecular and cellular basis of cancer as well as the anti-cancer properties of phytochemicals obtained from our natural resources. This position will give me the opportunity to apply and further enhance my skills in cancer research. It will also help me to develop award winning research projects in my home country to enable the training of young and intended researchers as well as contribute to overcoming the sting of cancer in Nigeria and the world at large. Besides, I expect that my research output in terms of high-quality publications will open new directions that I believe will spark further interest in my research area. Furthermore, this position will provide me with the opportunity to work in another country and culture, develop local and international collaborations and networking and, at the same time, receive quality training and research through collaboration, data sharing and quality supervision. All these aspects will improve my team work, leadership and project management skills in addition to interdisciplinary, interpersonal and intercommunication skills, which are important indicators for a successful long-term academic career. I am confident that when granted this opportunity we will together conquer the cunning intricacies of cancer to advance good health worldwide.
Affective and Anxiety Disorders, Substance Use Disorders and Addiction in General.
I, Sylvester Ororume Atiri got interested in studying Psychology from the first day l attended a lecture in ‘’Introduction to Psychology’’, an elective course, as a first year Geography student. As fate would have it, l started studying Psychology three years later as a freshman in the same university. Interestingly, from my early days as an undergraduate Psychology student, l became interested in Developmental Psychology because of my exposure to a course titled ‘’Introduction to developmental Psychology’’. By the time l got to my third year, we were Introduction to Clinical Psychology which also caught my interest. The study of Abnormal Behaviour, a Clinical Psychology related course, also blew my mind, though it made me a bit emotional and l felt pity for people who might find themselves experiencing such challenges but another part of me felt a need to be in a position to offer help to such individuals, and from then on, l viewed Psychology from the perspective of Developmental and Clinical psychology and the need to offer help to those in need of Psychological intervention. I joined the services of University of Lagos in 2013 as an Assistant Lecturer and presently a Senior Lecturer. I have since been lecturing undergraduate and postgraduate students in Physiological and clinical Psychological related courses like Physiological Psychology, Substance abuse, Psychopharmacology Psychotherapy and so on to mention a few. My research focus covers a wide range of human issues aimed at elevating and improving human existence and contributing to knowledge. I have been involved and still involved with studies involving hospital patients. I am also involved in practice as a Clinical Psychologist, helping with intervention for those experiencing Psychological challenges with Mayfield Medical Clinic, Nigeria.
National Centre for Technology Management, Ile-Ife, Osun State Nigeria
Health Innovation System, Quality of life, Behavioural determinants of health and End-of- life interventions
My interest in behavioural health studies was spurred after my first opportunity to study Psychology in the University. Though I had never heard of the course prior to my offer of admission, I was convinced of my interest in helping people feel better about themselves and was always eager to offer advice to individuals in need. I swiftly dived into the field of psychology, even beyond my required scope of work. Interestingly, I discovered that psychology is a cross-disciplinary, open-minded science of understanding people’s actions and inactions. Given this insight and apt diligence, I graduated with a First Class Honours and the best graduating student in my class. To further quench my thirst for knowledge, I bagged M.Sc and Ph.D degrees in Psychology with special interest in understanding the behavioural and theoretical underpinnings of cancer prevention and health promotion. Globally, cancer is the second leading cause of death, with the number of deaths exceeded only by cardiovascular diseases. In managing cancer, depressive and anxiety symptoms are the most common associated emotional symptoms reported by cancer patients. This situation is of particular importance because psychological symptoms are not only associated with lower quality of life but may lead to other difficulties such as poorer treatment adherence. Given this, cancer remains a source of concern in Nigeria, and therefore my interest in the field of psycho-oncology. I am a member of the Nigerian Psychological Association (APA) and Healthcare Administrators Association of Nigerian (HAAN). My research interests are directed towards understanding human behaviour especially in helping to improve individual health outcomes and psychological well-being. Asides my primary duties at my place of work as a behavioural scientist, I volunteer as a health psychologist and counsellor at “PsychCare Rehabilitation and Health Promotion Centre” where I use my expertise to assess, diagnose and manage mental, emotional, and behavioural disorders. The qualities I would rank as my strengths are my ability to think logically as well as being self-motivated. My short-term research goals are directed toward understanding human behaviour by engaging in theoretical, experimental, meta-analysis and inquiries as well descriptive studies in the area of psycho-oncology. My medium-term research plans are aimed towards the formulation of new concepts on human behaviour and developing models that will benefit patients, community, healthcare workers and Nigeria’s healthcare system at large. My ultimate aim is to come out with better understanding of the dynamics of cancer screening uptake, the quality of life of cancer survivors and client based therapy approach for helping patients diagnosed and living with cancer and other terminal illnesses. The interdisciplinary nature of the one-year postdoctoral research training position at Memorial Sloan Kettering Cancer Center in New York fits well with my academic and research pursuits as I am comfortable working in form of collaboration with nurses, epidemiologist, molecular biologists, and other relevant scholars. In particular, the training will further help to hone my skills in designing, implementing and monitoring the impacts of cancer researches in Nigeria. I am in particular optimistic that the training will help improve my knowledge of quantitative and qualitative methods, intentions of cancer screening, cognitive processes, social and humanistic perspectives as related to psycho-oncology studies and end of life interventions. Yours faithfully
My area of research interest is chronic disease care across all ages and settings. I have conducted interventional studies on the burden of sickle cell disease as a chronic illness and occupational health hazards related to cancer risks among nurses and other health professionals. I have been involved in collaborative research to explore the community perspective on coping with chronic diseases like cancer to deduce the challenges faced by people living with cancer to help oncology nurses develop a program that will promote the psychological, spiritual, social, and cultural perspectives of coping with chronic diseases.
I am a community/public health specialist and a senior lecturer in the Department of Nursing Science, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. I obtained my BNSc, MSc. and PhD in Nursing degrees from the University of Ibadan, Ibadan Oyo-State, Nigeria in 2004, 2008 and 2020. My primary research interest is in chronic disease care, including oncology care resulting from occupational hazard exposure predisposing health care professionals to cancer risk. This focuses on promoting healthy lifestyle practices (Self-care practices of individuals, families and community support) towards preventing and managing cancer and chronic diseases across ages.
My immediate goal in participating in this training is to acquire knowledge that will enhance my writing skills and widen my scope in cancer prevention and management across vulnerable populations. Also, I intend to publish two or more articles in high-impact journals. At the same time, the intermediate goal will allow me to independently expand my research skills to write an award-winning grant and improve my skill in analysis and qualitative study. I wish to collaborate with others in developing care protocol as a benchmark for cancer prevention and management across ages in primary, secondary, and tertiary health facilities. In the long run, I aspire to become a specialist in oncology and an erudite scholar promoting the quality of life of persons living with chronic diseases (cancer). Also, I look forward to upcoming mentoring professionals and young academics within my speciality to replicate and build upon before retirement.
My research interests are cancer prevention, quality improvement in oncology nursing services, and health system strengthening in Nigeria, a Low to Middle-Income Country (LMIC). My research focuses on improving and addressing gaps in the unmet needs in oncology nursing and health services research more effectively. My research area of interest is in line with the global call for action to contribute to the reduction in the incidence and prevalence of cancer. I am highly optimistic that the postdoctoral fellowship will build on my analytic skills and techniques. I consider this an essential part of my development as I move toward the next phase of my academic career.
I am a Community/Public Health Specialist and a Senior Lecturer in the Department of Nursing Science, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria. I obtained my B.Sc., M.Sc. and PhD degrees in Nursing from the same institution in 2006, 2013 and 2018, respectively. My nursing science background in developing theories and practical concepts for improving clinical nursing care through a multi-dimensional lens in exploring new and better ways to deliver health services affords me a sound understanding of the subject. My primary research interest is maternal, and child health with interest in women’s health and research focus on gynaecological oncology, especially Cervical Cancer (CC) Prevention and health system strengthening. I am a member of the Oncology Nursing Society (ONS) in Nigeria and the Gynaecological Oncology Society of Nigeria, a professional association committed to promoting excellence in oncology care and the transformation of cancer care. I have rich experience in community-based projects, including community engagement programs, health systems strengthening and health services research. Also, I have been involved in providing and supporting community out eaches on cancer prevention. I am a team leader of the Christian community medical outreaches aimed at healthcare services in the communities and grassroots Southwestern Nigeria. Also, I led a team of nurses to set up and integrate cervical cancer screening centres in four selected health care facilities in Osun State. Currently, I sit as a member of the Nursing and Midwifery Council of Nigeria Research Committee, and I participated in an ad-hoc committee to write a proposal for the development and establishment of a Nigerian Institute of Nursing Research (NiNuR).
My short-term career goal at the end of the training is to strengthen my research and analytic skills in cancer research. I also would like to publish in high-impact and reputable journals. I am therefore looking forward to being mentored by a researcher who has research experience in cancer care and prevention, working knowledge of Low-Middle Income Countries and has published extensively in reputable journals. Furthermore, I desire to acquire research skills in multi-level analysis using secondary data. I anticipate achieving a medium career goal through mentorship to write a proposal for an award-winning grant for a scale-up programme of my completed pilot project. In addition, I look forward to developing my mentorship skills and training on capacity building in monitoring and evaluating cancer care and prevention interventions with an emphasis on oncology nursing in sub-Saharan Africa. I am willing to participate in collaborative research, routine seminars, and workshops, possibly audit a couple of courses and acquire leadership and mentoring skills. I am committed to returning to my position in my home institution after completing a postdoctoral fellowship to implement the feasibility of scaling up CC prevention programmes in my country. I am highly optimistic that it is feasible to collaborate with such a highly esteemed organisation to enhance my research process, outcome, and eventual dissemination. My long-term career goal is to be involved in networking and collaborative research geared towards proffering solutions to prevailing reproductive health problems among the teeming population in our resource-constrained society. Furthermore, I aspire to become an erudite and seasoned oncology nurse who will serve as an oncology expert, a consultant of international reputation and a great mentor to upcoming scholars in oncology nursing. Therefore, given the opportunity, the training will induct me into o the league of seasoned researchers and add value to your organisation.
Memorial Sloan Kettering Cancer Center, New York, USA
Re: Postdoctoral Research Associate
I, Adeleye Adeomi, a lecturer/researcher and a honorary Consultant in Public Health at Obafemi Awolowo University and Obafemi Awolowo University Teaching Hospital Complex, Nigeria respectively, hereby indicate my interest in the post of postdoctoral Research Associate in your highly esteemed organization. I wish to firstly note that I fit all the inclusion criteria for the post. I have recently completed my Ph.D. program in the School of Public Health, University of the Witwatersrand, Johannesburg, South Africa. Secondly, I am an epidemiologist, with special interest in Nutritional epidemiology. I also have extensive experience with research, and publication of manuscripts. I also have experience working with people of diverse backgrounds and disciplines. This could be easily seen in the publications in my CV where I have collaborated with more than 80 researchers of diverse backgrounds and disciplines. I am also proficient with research conceptualization, manuscript writing, both quantitative and qualitative data collection and analysis and presentations. Additionally, other important qualities that I will bring to the project are my impressive work ethic, high level of self-discipline, readiness to learn always and a very high sense of responsibility. I have also won many academic awards and distinctions which include federal government scholarship for gifted and talented children for my secondary school (high school) education, and the overall best candidate in the class of 2012 Master of Public Health (MPH) program, Obafemi Awolowo University, Ile-Ife. I won three (3) out a total of seven (7) National awards of the National postgraduate Medical College of Nigeria during my residency/post-graduate training as a public health consultant. In the same vein, I am a fellow of the Consortium for Advanced Research Training in Africa (CARTA), a prestigious and competitive fellowship in Africa. My short-term career goal is to consolidate my research and data management skills, while my medium-term goal centers on building the critical network for, attraction of, and management of research grants and my long-term goal is to contribute significantly to the prevention and management of non-communicable diseases (including cancers and cardiometabolic diseases) through nutritional epidemiology. This organization, being a research-based organization with extensive experiences in data management (including large data), grantsmanship and landmark researches in cancer epidemiology, will help to advance my career goals to a great extent; hence my interest in this position. I would be grateful if my application is favorably considered, and will be willing to commit my best into the postdoctoral training and every activity involved in the research.
Associate Professor/Acting Head of Department, Community Medicine
Niger Delta University/Niger Delta University Teaching Hospital, Bayelsa State
I have been largely involved in infectious disease research with particular interest in malaria, healthcare associated infections, and HIV/AIDS. Currently, I am interested in: 1. Cancer risk assessment of environmental pollution. 2. Accessibility to cancer screening, diagnostic and treatment facilities for underserved populations. 3. Health seeking behavior and late presentation of cancer in health facilities.
I wish to apply for the Post-Doctoral Research Training Program to acquire new knowledge and strengthen my research skills to improve public health/clinical practice in cancer prevention and management. I wish to be part of the cohort of highly skilled and accomplished investigators that will be at the forefront of leading independent oncology research, build capacity of early researchers including resident doctors and other health workers in Nigeria, provide mentorship and lead inter-university collaboration. I wish to provide leadership in innovative public health solutions for cancer management through cutting-edge research and international partnership. I have been practicing as a Public Health Physician for more than 10 years after the completion of my Fellowship Program in Public Health at the National Postgraduate Medical College of Nigeria. I joined the Department of Community Medicine at the Niger Delta University in 2012 as Lecturer 1. I was appointed as an honorary Consultant Public Health Physician to the Niger Delta University Teaching Hospital and serve as the Hospital Epidemiologist. Before I joined the University/Teaching Hospital, I served as Bayelsa State Epidemiologist. Nigeria is facing a double epidemic of infectious and non-communicable diseases (NCDs). Most of the resources including lecturers and researchers are inclined towards infectious diseases; very little research and funds go into NCDs of which cancer is a significant part. The apparent dearth of human resources in cancer control coupled with the personal loss of some close relatives and colleagues stimulated my current interest in cancer control and prevention. Additionally, our department teaches epidemiology and research methods to medical and postgraduate students in the College of Health Sciences but none of the faculty has an advanced training in non-communicable disease epidemiology. It is my desire, as the Acting Head of Department, to introduce cancer research and epidemiology to the University and the Teaching Hospital. As a result of my passion for cancer management, I joined the Breast Cancer Association of Nigeria (BRECAN) which is actively fighting breast and cervical cancers (the two leading cancers among women) and is strategizing to include prostate cancer among its cancers of focus. I am the secretary of the Bayelsa State chapter of the association and the Chairman of its research committee. At the national level of BRECAN, I am a member of the Technical Committee which is responsible for the research pillar of the association. Importantly, BRECAN is a member of the Union for International Cancer Control (UICC). I also initiated and am coordinating Coalition Against Cancer in Bayelsa State (CACIBS), a non-governmental organization working with Bayelsa State Ministry of Health to strengthen its cancer control activities and to facilitate the establishment of a cancer control program for the state. I am currently supervising a Master’s project titled “Availability of and utilization of cervical cancer screening services by women of child bearing age in Bayelsa State”. This is to assess how close Bayelsa State is to achieving the screening component of the 90-70-90 targets of the Global Eradication of Cervical Cancer Initiative and to make recommendations that will accelerate efforts towards achieving the targets. As a result of increasing oil exploration activities leading to oil spillage, gas flaring and other forms of environmental pollution that expose to carcinogens, there is anecdotal evidence of increased cancer incidence in Bayelsa State. Unfortunately, there is no population-based cancer registry in the state and the only facility-based registry is severely constrained by lack of staff that can assess risk factors. Through this post-doctoral training program, I wish to contribute to the building of a critical mass of cancer experts that will conduct advanced research and compete for research and intervention grants to improve cancer control in Bayelsa State and in Nigeria as a whole and I look forward to initiating the establishment of an oncology research center in my institution. I am confident that the international collaborative environment and the renowned faculty involved in this fellowship program will prove to be a stimulating learning and capacity building experience for me.
Department of Nursing Sciences, College of Medicine and Health Sciences, Afe Babalola University, Ado-ekiti, Nigeria
Cancer risk factors and prevention, cancer Screening, Environmental carcinogens and Public Health Nursing research.
Cancer is becoming a leading cause of morbidity and mortality in low, middle and high-income countries, with increasing incidence globally. Cancer is often seen as a death sentence in the African context, and as a result, accepting cancer diagnosis, informing patients and family members about the disease and associated side effects with varied treatment options, most often than not, cause psychological distress to patients. Most cancer diagnosis are made at advanced stages majorly due to ignorance on the cause and the risk factors of the disease, available screening services and also as a result of limited cost-effective screening services available for the Nigeria populace. In Nigeria, many cancer patients report to the hospital late when cancer prognosis is poor which has in turn reduced the survival rate of cancer related deaths in Nigeria. Simple measures such as encouraging Health promotive lifestyle and early detection and screening through population awareness raising activities and mass screening campaigns could help to improve the current diagnosis and prognosis of cancer treatment in Nigeria thus improving cancer related outcome in the Nigeria populace. I believe with continuous increase in awareness raising activities aimed at demystifying the populace’ mind on the causes/risk factors of the disease will go a long way in promoting populace’ utilization of available screening options for the varied cancers, which in turn will promote early detection of certain cancers and improve the health seeking behavior Nigerians, thus reducing the morbidity and mortality associated with cancer disease in Nigeria with improved life expectancy of the affected individuals. I believe a postdoctoral program in cancer research from your renowned institution will better equip me in the area of cancer research which will be of immense benefit to the citizen of my home country. I will also benefit immensely from the wealth of your faculty members in your prestigious institution. I would be grateful if my application is considered.
Personal Statement My prior research experience has been in both clinical and laboratory and my main career interest is on cancer research. I have had a long-held interest in understanding the molecular basis of cancer and how this can help improve diagnostics, and treatment outcome, especially in my environment. This underlying passion fueled my clinical cum research career and lead me to undertake a postgraduate research (PGR) program in cancer medicine / molecular biology at the University of Liverpool, England. My PGR project was on the molecular transformation of pre-malignant lesions using high throughput sequencing, and it was based on my hypothesis that “a single gene – single pathway alteration is responsible for this transformation” – this hypothesis was propounded following a published systematic review. My experiments included designing a pilot study for hypothesis generation of data to evaluate the workability of my assay, justification of my sample size i.e., power calculation, and for result validation experiments. There remains an environment-genetic risk factor interaction with emphasis on race and geographical location, and this is especially significant amongst Africans whose genetic pool exhibits a higher genetic diversity than Eurasians, and this avails an opportunity for more targeted therapy and improved precision medicine. Cancer is the leading cause of death worldwide and cervical cancer is the 4th leading cancer by incidence with >85% occurring in LMICs. My proposed project for this post-doctorate position is titled “Appraisal of dual p16/Ki-67 immunochemistry (IHC) self-sampled pap smear as surrogates for transforming HPV infection, to scale up cervical cancer screening in LMICs”. The goal is to reduce the high incidence of cervical cancer morbidity in LMIC through a simpler and cheaper diagnostic assay here referred to as “Dual p16/Ki-67 IHC”. Works that led to this project include; my knowledge of molecular biology techniques (TMA, gene-expression analysis – IHC, qPCR, pyrosequencing; western-blot), clinical trial and next generation sequence courses attended, and lastly my literature review which showed evidence of a lack of LMIC cervical cancer data. My career goals are two folds – research and academics. My research goal is to acquire skills and develop knowledge to allow me undertake research on regional pathogenesis and generate data to help improve preventive interventions, diagnostics, and therapy. It may be of interest that quite several research databases for pathogenesis are based mostly on Eurasian ethnicity which is reported to contribute only a subset to the entire genome variants, and this implicitly contributes to intervention and therapeutics for that group-set. Besides, the genetic variants seen outside of African population is generally a subset of that seen within the African population genome. Several molecular genetic studies have provided ample evidence of overlap in disease-risk alleles, along ancestry lines and diverse communities and this scenario is reported to improve the ability to detect newly associated disease loci and improve causal variant mapping. My academic goals are to ensure capacity building through mentoring of junior colleagues. This is another passion of mine which I have undertaken on the last 20 years. I have trained specialist doctors at the bedside, and I hope to do same by the bench. My short-term goals are to improve on my acquired PGR knowledge which this application would offer me. I also hope to develop in the mid-term, the requisite network from this post-doctorate and undertake further studies as my collaborators deem necessary. In the long term, I hope to undertake collaborative research leading to the setting up of my laboratory and the development of my region. I think Africa still has a lot to offer the outside world.